Exploring the binding of anticancer drug BI-3802 to DNA using optical tweezers
نویسندگان
چکیده
BI-3802 is a relatively new anticancer drug known to bind the transcription repressor BCL6 and potently kill most common form of cancer cells, B-cell lymphoma, found in lymphatic system. Based on its structure we believe this small molecule can DNA through intercalation. We use Optical tweezers trap single explore binding with DNA. Once molecule, stretch measure tension as function extension.
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2022
ISSN: ['0006-3495', '1542-0086']
DOI: https://doi.org/10.1016/j.bpj.2021.11.1337